LYSOSOMAL ACID LIPASE A MODULATES LEUKEMIA STEM CELL RESPONSE TO VENETOCLAX/TYROSINE KINASE INHIBITOR COMBINATION THERAPY IN BLAST PHASE CHRONIC MYELOID LEUKEMIA

The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug chicago cubs earrings resistance of leukemia stem cells (LSCs).Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-targeting tyrosine kinase inhibitors (TKIs) can eradicate bpCML LSCs.In this repor

Abstract Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations.Non-hospitalised participants within 5 days of SARS-CoV-2 symptoms randomised to receive molnupiravir (n = 253) or Usual Care (n = 324) were kicker pro comp 10 recruited to study viral and antibody dynamics and the eff

The regulation of cellular zinc uptake is a key process in the overall mechanism governing mammalian zinc homeostasis and how zinc participates in cellular functions.We analyzed the zinc transporters of the Zip here family in both the brain and liver of zinc-deficient animals and found a large, significant increase in Zip10 expression.Additionally,

It is an undeniable fact that mission remains the cardinal essence of the Church.However, in Africa and in Nigeria, the Church seems to have lost focus regarding the main reason for its existence, namely mission.One of the factors responsible for this may be the form of theological education in vogue.In view of this anomaly, this paper reflects on